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Now, scientists at Washington University School of Medicine in St.Louis report they have been able to achieve — with a custom-built microscope — the closest view yet of living nerve synapses.

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Understanding the detailed workings of a synapse — the junction between neurons that govern how these cells communicate with each other — is vital for modeling brain networks and understanding how diseases as diverse as depression, Alzheimer’s or schizophrenia may affect brain function, according to the researchers.